The New Penicillins in Endocarditis

The New Penicillins in Endocarditis.

FEW infections can kill a human being as rapidly as acute staphylococcal endocarditis in its most fulminant form. Infections caused by penicillinase producing staphylococci have been particularly difficult to manage. Successful treatment has been 'accomplished by combinations of antibiotics, by vancomycin, and even by huge doses of penicillin G. Still, the problem of therapy remains formidable....

Treatment of Bacterial Endocarditis with Oral Penicillins.

Biosynthesis of penicillins; new crystalline biosynthetic penicillins.

Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...

Prevention of Bacterial Endocarditis in Dentistry: the New Guidline

The American Heart Association (AHA) has provided new guidelines for infective endocarditis prophylaxis in dentistry. In this paper, written for dentists, major changes in the updated recommendations which dentists should be aware have been discussed. These recommendations address the impact of oral hygiene and type of dental procedures on high-risk patients, risk of adverse reactions of antibi...

Some new biosynthetic penicillins.

In our laboratories some 200 compounds, including phenylacetic acid derivatives, have been studied as possible precursors for new penicillins, and several of these appeared to give rise to new penicillins. In this report, five new penicillins, four of which were obtained in crystalline form, are described and their production, isolation, and characterization discussed. The methods employed in o...